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| − | '''17 July 2019:''' ''A flashback on unsaturated glucuronyl hydrolases:'' Back in 2015, [[Author]] '''[[User:Seino Jongkees|Seino Jongkees]]''' essentially completed the '''[[Glycoside Hydrolase Family 88]]''' page, which was finally upgraded to [[Curator Approved]] status today. '''[[GH88]]''' unsaturated glucuronyl hydrolases use an atypical [[glycoside hydrolase]] mechanism that involves the hydration of the double bond between carbons 4 and 5 of the non-reducing terminal sugar of their substrates and subsequent rearrangement. In this way, the action of '''[[GH88]]''' enzymes is dependent on the prior action of [[Polysaccharide Lyases]] to produce the required hexenuronic acid terminus. ''Learn more about these non-canonical enzymes, and their cousins in [[GH105]], on the '''[[GH88]]''' page''. | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | '''15 July 2019:''' ''Of carbohydrates, esters, and lignin:'' [[Author]]s '''[[User:Jenny Arnling Bååth|Jenny Arnling Bååth]]''' and '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''', together with [[Responsible Curator]] '''[[User: Johan Larsbrink| Johan Larsbrink]]''' finalized ''CAZypedia's'' third [[Carbohydrate Esterase Families|Carbohydrate Esterase Family]] page today. '''[[Carbohydrate Esterase Family 15]]''' comprises glucuronoyl esterases that utilize a classical serine hydrolase catalytic triad to cleave pendant non-carbohydrate groups from, for example, plant glucuronoxylan (''i.e.'' [https://doi.org/10.1016/j.sbi.2005.10.008 de-esterification with the sugar as the acid]). '''[[CE15]]''' members have therefore be suggested to facilitate the breakdown of lignin-carbohydrate complexes (LCC) and are of growing interest for biomass processing. ''Learn more about these enzymes, including the seminal work of Peter Biely and colleagues, on the '''[[CE15]]''' page''. | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''5 June 2019:''' ''New and cool beta(1,2)-glucanases of GH162:'' Today [[Author]] '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' and [[Responsible Curator]] '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' completed the '''[[Glycoside Hydrolase Family 162]]''' page in ''CAZypedia''. As its high number would imply, '''[[GH162]]''' is one of the newest families in the CAZy classification, of which the first example has been elegantly characterized in 2019 by Drs. '''[[User:Nobukiyo Tanaka|Tanaka]]''' and '''[[User:Masahiro Nakajima|Nakajima]]''' and their colleagues. '''[[GH162]]''' is a tiny family of mostly fungal members, which has structural and mechanistic commonality with [[GH144]], and may be distantly related to [[GH8]] ([[Clan]] GH-M) and [[GH15]] ([[Clan]] GH-L). ''Learn more about all of these families on their respective pages''.
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| − | '''14 May 2019:''' ''Starch... it's not over yet:'' Two new families of starch-binding CBMs, '''[[CBM82]]''' and '''[[CBM83]]''', have joined the CAZypedia ranks. These CBMs are both found in an enormous multi-modular cell-wall anchored enzyme from a gut bacterium. The pages were both authored by '''[[User:Darrell Cockburn|Darrell Cockburn]]''' with '''[[User:Nicole Koropatkin|Nicole Koropatkin]]''' acting as responsible curator. ''Learn more about the new starch-binding '''[[CBM82]]''' and '''[[CBM83]]''' families on their respective pages''.
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| − | '''28 February 2019:''' ''CE9 is CE page #2!:'' Graduate student '''[[User:Alex Anderson|Alex Anderson]]''' has completed ''CAZypedia's'' second [[:Category:Carbohydrate Esterase Families|Carbohydrate Esterase (CE)]] family page, '''[[Carbohydrate Esterase Family 9]]''', which was [[Curator Approved]] by his supervisor '''[[User:Michael Suits|Michael Suits]]''' today. '''[[CE9]]''' enzymes are metal-dependent ''N''-acetylglucosamine 6-phosphate deacetylases that function in peptidoglycan recycling in bacteria. '''[[CE9]]''' is a huge family, currently comprising over 10,000 members (nearly all are from bacteria), which underscores their biological importance. '''[[User:Alex Anderson|Alex]]''' and '''[[User:Michael Suits|Mike]]''' completed ''CAZypedia's'' first [[:Category:Carbohydrate Esterase Families|CE family page]], [[CE4]] earlier this month, and we thank them for these seminal expansions of of our resource. ''Learn more about the structure and mechanism of metal-dependent deamidases here: [[CE9]], [[CE4]]''.
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31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.