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| − | '''17 January 2014:''' ''More on CBMs:'' The '''[[Carbohydrate Binding Module Family 41]]''' page was upgraded to [[Curator Approved]] status today by '''[[User:Alicia Lammerts van Bueren|Alicia Lammerts van Bueren]]''' and '''[[User:Al Boraston|Al Boraston]]'''. '''[[CBM41]]''' is a family of alpha-glucan-binfing modules, which are primarily associated with the pullulanases and amylases of [[Glycoside Hydrolase Family 13]]. ''Find out more [[Carbohydrate Binding Module Family 41|here...!]]'' | + | '''31 October 2025:''' ''A spooktacular addition to the CAZypedia family!'' Come and say 'Boo!' to the frighteningly well written '''[[CBM13]]''' ''CAZypedia'' page. The '''[[CBM13]]''' family is a '''[[Carbohydrate-binding_modules#Blurred Lines: CBMs, Lectins and Outliers|lectin-like CBM family]]'''. Its first characterized members were lectins, including the B chain from the highly toxic [https://en.wikipedia.org/wiki/Ricin ricin] toxin from ''Ricinus communis''. This spine tingling read was authored by '''[[User:Scott Mazurkewich|Scott Mazurkewich]]''' and '''[[User:Lauren McKee|Lauren McKee]]''' who also acted as responsible curator. ''Come and visit the scariest of ''CAZypedia'' CBM pages, '''[[CBM13|here!]]'''... if you dare...'' |
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| − | '''6 January 2014:''' ''A new year, a new CBM page!'' The '''[[Carbohydrate Binding Module Family 6]]''' page was completed and given [[Curator Approved]] status today by [[Author]] and [[Responsible Curator|Curator]] '''[[User:Mirjam Czjzek|Mirjam Czjzek]]'''. '''[[CBM6]]''' was originally defined based on the observation of xylan binding, however the diversity of substrate specificities in this family has now grown to include diverse beta-glucans, chitin, and even the marine polysaccharide agarose; remarkably, some '''[[CBM6]]''' members also contain two distinct binding sites. The '''[[CBM6]]''' page is ''CAZypedia's'' second [[Carbohydrate Binding Module Families|Carbohydrate Binding Module Family]] page, and we [[Carbohydrate_Binding_Module_Families#Under_construction|look forward]] to the further expansion of this section in the new year! | + | '''29 July 2025:''' ''[[CBM91]] is in the news!'' The xylan binding '''[[CBM91]]''' family ''CAZypedia'' page is up and running. Appended to mainly [[GH43]] xylanases this [[CBM91]] family drives interaction with substrate. The [[CBM91]] page was authored by '''[[User:Daichi Ito|Daichi Ito]]''' who also discovered the initial xylan-binding function which resulted in the creation of the [[CBM91]] CAZy family. ''Read up on this industrially interesting '''[[CBM91]]''' family '''[[CBM91|here]]'''.'' |
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| − | '''18 December 2013:''' ''A new mannanase page:'' Today, '''[[User:Rohan Williams|Rohan Williams]]''' and '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 113]]''' page. '''[[GH113]]''' is currently a very small family (120 members) with only one characterized member, the ''Alicyclobacillus acidocaldarius'' beta(1-4)-mannanase. The seminal crystal structure of this enzyme revealed '''[[GH113]]''' to be a member of [[Clan]] GH-A. A recent publication from the '''[[User:Spencer Williams|Williams]]''' team and collaborators illuminated further details of the '''[[GH113]]''' and '''[[GH26]]''' transition states using designed inhibitor-enzyme complexes. ''Read more about this emerging family [[Glycoside Hydrolase Family 113|here]]!''
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| − | '''New for fall 2013:''' ''The CAZy database [http://dx.doi.org/10.1093/nar/gkt1178 now presents enzyme ligands!]'' See any family's [http://www.cazy.org/GH5_structure.html "Structure" page] for examples.
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| − | '''6 October 2013:''' '''''[[GH66]]''' page upgraded to [[Curator Approved]] status:'' Today, [[Responsible Curator]] '''[[User:Zui Fujimoto|Zui Fujimoto]]''' formally approved the '''[[Glycoside Hydrolase Family 66]]''' page, [[Author]]ed by '''[[User:Ryuichiro Suzuki|Ryuichiro Suzuki]]''', as complete and ready for public viewing. '''[[GH66]]''' is a very small family, currently containing ca. 60 members, of α(1-6)-glucan hydrolases (a.k.a. dextranases) and cyclo-isomalto-oligosaccharide glucanotransferases. Through a series of elegant studies including biochemical and crystallographic analyses, '''[[User:Zui Fujimoto|Dr. Fujimoto]]''' and his collaborators have provided direct insight into catalysis by this unique family. ''Read more about the long history of these enzymes [[Glycoside Hydrolase Family 66|here]]!''
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| − | '''30 September 2013:''' ''Our first PL page!:'' '''[[User:Wade Abbott|Wade Abbott]]''' finalized ''CAZypedia's'' first [[Polysaccharide Lyase Families|Polysaccharide Lyase Family]] page, '''[[PL2]]''', today. As with our recent foray into [[Carbohydrate Binding Module Families|CBM families]] (see our May 22 news item) the extension of ''CAZypedia'' to include the [[Polysaccharide Lyase Families|PLs]] ushers in a new phase in our development, and we are very much looking forward to the evolution of this new group of pages, spearheaded by '''[[User:Wade Abbott|Wade Abbott]]''' and '''[[User:Michael Suits|Michael Suits]]'''. ''If you are an expert on any of the [http://www.cazy.org/Polysaccharide-Lyases.html 22 PL families in the CAZy Database] and would like to contribute to ''CAZypedia'', please contact us [[Special:Contact|here]].
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31 October 2025: A spooktacular addition to the CAZypedia family! Come and say 'Boo!' to the frighteningly well written CBM13 CAZypedia page. The CBM13 family is a lectin-like CBM family. Its first characterized members were lectins, including the B chain from the highly toxic ricin toxin from Ricinus communis. This spine tingling read was authored by Scott Mazurkewich and Lauren McKee who also acted as responsible curator. Come and visit the scariest of CAZypedia CBM pages, here!... if you dare...
29 July 2025: CBM91 is in the news! The xylan binding CBM91 family CAZypedia page is up and running. Appended to mainly GH43 xylanases this CBM91 family drives interaction with substrate. The CBM91 page was authored by Daichi Ito who also discovered the initial xylan-binding function which resulted in the creation of the CBM91 CAZy family. Read up on this industrially interesting CBM91 family here.