User:Ana Luis

I obtained a M.Sc in Pharmaceutical Sciences at Universtiy of Lisbon in 2009. After I worked with Dr. Carlos Fontes at Technical University of Lisbon, studying the mechanisms of protein-carbohydrate interactions. Between 2013 and 2017 I moved to Newcastle University (UK) to do my PhD under the supervision of Prof. ^^^Harry Gilbert^^^. During this time I studied the mechanisms behind pectin degradation and utilization by the gut bacterium Bacteroides thetaiotaomicron. I’m currently a PostDoc mentored by Prof. Gunnar C. Hansson (University of Gothenburg, Sweden) and Eric C. Martens (University of Michigan, USA). My research is focused on functional and structural characterization of enzymes and carbohydrate-binding modules. I'm currently interested in understanding the mechanisms behind mucin degradation by gut bacteria and its implications in inflammatory bowel disease.

I contributed to structural-functional characterization of:

• CBM65 from Eubacterium cellulosolvens (Family First structure and description of substrate recognition) [1]
• CBM77 from Ruminococcus flavefaciens (Family First) [2]
• GH106 BT0986 and BT4145 from Bacteorides thetaiotaomicron (Family First structure and mechanism of catalysis description) [3, 4]
• GH103 BT1003 from Bacteorides thetaiotaomicron (first report of an aceric acidase enzyme) [3];
• PL9 BT4170 Bacteroides thetaiotaomicron (first rhamnogalacturonan lyase inside PL9 family) [4];

---

Error fetching PMID 23229556:
Error fetching PMID 27298375:
Error fetching PMID 28329766:
Error fetching PMID 29255254: