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Difference between revisions of "Template:News"

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'''19 January 2015:''' ''Still in the high 70's today:'' '''[[User:Zui Fujimoto|Zui Fujimoto]]''' brought the '''[[Glycoside Hydrolase Family 78]]''' page up to [[Curator Approved]] status today, making that ''CAZypedia's'' 97th approved GH page. '''[[GH78]]''' is a family of archaeal, bacterial, and fungal alpha-rhamnosidases that cleave diverse flavonoid glycosides, polysaccharides, glycoproteins, and glycolipids from plants.  ''Read more on these ecologically relevant enzymes [[Glycoside Hydrolase Family 78|here]].''
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'''19 July 2024:''' ''Chalk-up one more for the GTs!'' The '''[[Glycosyltransferase Family 47]]''' page joined the small group of [[Curator Approved]] [[Glycosyltransferase Families]] pages in ''CAZypedia'' today. This entry was [[author]]ed by Ph.D. students '''[[User:Daniel Tehrani|Daniel Tehrani]]''' and '''[[User:Charlie Corulli|Charlie Corulli]]''', and [[Responsible Curator|Curated]] by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' with input from '''[https://ccrc.uga.edu/team/kelley-moremen/ Kelley Moremen]'''. Widely represented in plants, '''[[GT47]]''' members are anomer-[[inverting]] [[glycosyltransferases]], which are involved in the biosynthesis of several cell wall matrix polysaccharides.  Representatives from mammals are involved in heparin biosynthesis.  Correspondingly, members of [[GH47]] have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides.  ''This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!''
 
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'''7 January 2015:''' ''Love your guts:'' ''CAZypedia'' is ringing in the new year with a new '''[[Glycoside Hydrolase Family 76]]''' page by '''[[User:Spencer Williams|Spencer Williams]]'''.   '''[[GH76]]''' contains endo-acting α-mannanases, including members from the human gut bacterium ''Bacteroides thetaiotaomicron'' that enable us to degrade yeast mannans in our diet.  A very recent publication in ''Nature'', notably involving ''CAZypedia'' contributors '''[[User:Michael Suits|Michael Suits]]''', '''[[User:Al Boraston|Al Boraston]]''', '''[[User:Spencer Williams|Spencer Williams]]''', '''[[User:Gideon Davies|Gideon Davies]]''', '''[[User:Wade Abbott|Wade Abbott]]''', and '''[[User:Harry Gilbert|Harry Gilbert]]''', has recently shed new light on the structure, mechanism, and biological function of these enzymes.  ''Read more [[Glycoside Hydrolase Family 76|here]]!''
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'''9 July 2024:''' ''Yet another new family of beta-1,2-glucan-active enzymes!'' Today, '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 186]]''' page by '''[[User:Sei Motouchi|Sei Motouchi]]'''. '''[[GH186]]''' is a family of anomer-[[inverting]] enzymes from bacteria, members of which are specific for beta-1,2-glucans.  Intriguingly, although some [[GH186]] members work as classic [[glycoside hydrolases]], others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack.  Also notable, [[GH186]] members appear to use an extended chain of water molecules to relay acceptor deprotonation by the [[general base]] residue, ''i.e.'' a [https://en.wikipedia.org/wiki/Grotthuss_mechanism Grotthuss mechanism]. ''Check out the '''[[GH186]]''' page to learn more about these interesting enzymes, and make sure to see the [[GH189]], [[GH144]], and [[GH162]] pages from this same group.''
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'''11 September 2014:'''  ''Another PL family done:'' Today, '''[[User:Richard McLean|Richard McLean]]''' and '''[[User:Wade Abbott|Wade Abbott]]''' finished the '''[[Polysaccharide Lyase Family 22]]''' page, bringing the number of [[Curator Approved]] [[PL]] pages in ''CAZypedia'' to a total of 5 (of 23). '''[[PL22]]''' is a family of bacterial (and a handful of archeal) oligogalacturonide lyases (OGLs), archetypal members of which are highly specific for digalacturonate and Δ4,5-unsaturated digalacturonate ''i.e.'', they do not cleave polymeric α-(1,4)-linked galacturonan, a component of pectin. [[User:Wade Abbott|Wade]] performed a seminal crystallographic analysis of [[PL22]], and he and [[User:Richard McLean|Richard]] have produced a lucid distillation of the mechanism of catalysis in this family.  ''Read more [[Polysaccharide Lyase Family 22|here]]!''
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.  
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'''9 September 2014:''' ''2-for-1 Back to School Special:'' With the start of the new academic year, we are happy to report that two new [[Polysaccharide Lyase Families|Polysaccharide Lyase Family]] pages have recently been completed and given [[Curator Approved]] status.  In August, '''[[User:Naotake Konno|Naotake Konno]]''' and '''[[User:Shinya Fushinobu|Shinya Fushinobu]]''' produced the '''[[Polysaccharide Lyase Family 20]]''' page, which describes this small (currently, 18 member) group of bacterial and fungal beta-(1-4)-glucuronan-cleaving enzymes. ''And'', on the 7th of this month, '''[[User:Sine Larsen|Sine Larsen]]''' and '''[[User:Leila LoLeggio|Leila LoLeggio]]''' composed the '''[[Polysaccharide Lyase Family 4]]''' page.  Currently, '''[[PL4]]''' is only known to contain rhamnogalacturonan lyases involved in pectin degradation, notably including many plant sequences in addition to bacterial and fungal members.  We thank these [[Author]]s and [[Responsible Curator]]s for their contributions and encourage our readers to check out these new pages.
 
 
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Latest revision as of 09:56, 22 July 2024

19 July 2024: Chalk-up one more for the GTs! The Glycosyltransferase Family 47 page joined the small group of Curator Approved Glycosyltransferase Families pages in CAZypedia today. This entry was authored by Ph.D. students Daniel Tehrani and Charlie Corulli, and Curated by Breeanna Urbanowicz with input from Kelley Moremen. Widely represented in plants, GT47 members are anomer-inverting glycosyltransferases, which are involved in the biosynthesis of several cell wall matrix polysaccharides. Representatives from mammals are involved in heparin biosynthesis. Correspondingly, members of GH47 have diverse substrate specificities, including the transfer of both anionic and neutral monosaccharides to polysaccharides. This is a great example where two keen Ph.D. students worked with their supervisors to create a valuable page for the scientific community. We encourage others to follow their lead, on your favorite family!

9 July 2024: Yet another new family of beta-1,2-glucan-active enzymes! Today, Masahiro Nakajima Curator Approved the Glycoside Hydrolase Family 186 page by Sei Motouchi. GH186 is a family of anomer-inverting enzymes from bacteria, members of which are specific for beta-1,2-glucans. Intriguingly, although some GH186 members work as classic glycoside hydrolases, others perform transglycosylation by wrapping the sugar chain around in the active-site, to position the 6-OH group of a terminal glucosyl unit for direct attack. Also notable, GH186 members appear to use an extended chain of water molecules to relay acceptor deprotonation by the general base residue, i.e. a Grotthuss mechanism. Check out the GH186 page to learn more about these interesting enzymes, and make sure to see the GH189, GH144, and GH162 pages from this same group.

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

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