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User:Brian Mark

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Brian Mark obtained his BSc in Biology from the University of Winnipeg, Canada in 1995, which he followed with an MSc degree in Biochemistry from the University of Manitoba, Canada in 1998. He completed his PhD degree at the University of Alberta with Michael James in 2003, studying the structure and catalytic mechanism of human and bacterial N-acetyl-β-hexosaminidases (GH20). His postdoctoral research was carried out at Los Alamos National Laboratory, USA, working with Thomas Terwilliger and Geoffrey Waldo to develop new methods to enhance the solubility of recombinant proteins for structural analysis. In 2005, Dr. Mark returned to Canada and joined the Department of Microbiology, University of Manitoba as an Assistant Professor. He investigates the structural biology of enzymes within the Gram-negative peptidoglycan recycling pathway and how their products regulate the inducible expression of chromosomal AmpC beta-lactamase. The glycoside hydrolase NagZ (GH3) is of particular interest in this pathway since it produces a peptidoglycan metabolite that positively regulates AmpC beta-lactamase expression.