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• Responsible Curator: Bernard Henrissat

GH69 is a deleted family

Entries in GH69 were transferred to Polysaccharide Lyase Family 16 when it was shown that polysaccharide cleavage occurred via a beta elimination, rather than glycosidic bond hydrolysis [1, 2].

References

1. Baker JR, Dong S, and Pritchard DG. The hyaluronan lyase of Streptococcus pyogenes bacteriophage H4489A. Biochem J 2002 Jul 1; 365(Pt 1) 317-22. doi:10.1042/BJ20020149 pmid:12071858. PubMed HubMed [Baker2002]
2. Smith NL, Taylor EJ, Lindsay AM, Charnock SJ, Turkenburg JP, Dodson EJ, Davies GJ, and Black GW. Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix. Proc Natl Acad Sci U S A 2005 Dec 6; 102(49) 17652-7. doi:10.1073/pnas.0504782102 pmid:16314578. PubMed HubMed [Smith2005]

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