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Carbohydrate Binding Module Families
Note (January 2018): We are now in full development of our individual CBM pages in CAZypedia and our long-term goal is to have complete coverage of all of the CBM families represented in the CAZy database. This effort was initiated by Alicia Lammerts van Bueren, together with the Senior Curators, and is now being led by Elizabeth Ficko-Blean. If you would like to become involved in the development of the CBM pages, please contact Elizabeth Ficko-Blean directly, or using this form.
Carbohydrate-binding modules (CBMs) are non-catalytic proteins with the capacity to bind to soluble and crystalline carbohydrates. CBMs are typically found within a longer protein sequence, co-occurring with catalytic modules of carbohydrate active enzymes, e.g. Glycoside Hydrolases and Polysaccharide Lyases, where they serve to enhance the catalytic activity of the enzymatic module(s) [1, 2, 3, 4, 5, 6, 7]. For a comprehensive overview, see the Carbohydrate-binding modules Lexicon page.
Responsible Curator as essentially complete. CAZypedia is a living document, so further improvement of these pages is still possible; please see the individual pages for more information.
There are currently 25 Curator approved Carbohydrate Binding Module (CBM) Family pages in CAZypedia.
under construction in CAZypedia. As such, the Responsible Curator has deemed that the page's content is not quite up to CAZypedia's standards for full public consumption. All information on these pages should therefore be considered to be under revision and may be subject to major changes.
There are currently 15 Carbohydrate Binding Module Family pages Under construction in CAZypedia.
Unassigned pages are currently lacking a Responsible Curator and one or more Authors. If you are an expert on any of these families and would like to help us improve CAZypedia by getting involved with the production and maintenance of the corresponding page(s), please contact a member of the Board of Curators directly, or via this form.
All CBM Family pages not listed above are currently unassigned. Please contact us if you'd like to get involved with the creation of these pages.
There are currently 2 pages in CAZypedia that describe Carbohydrate Binding Module families deleted from the CAZy DB.
- Boraston AB, Bolam DN, Gilbert HJ, and Davies GJ. Carbohydrate-binding modules: fine-tuning polysaccharide recognition. Biochem J. 2004 Sep 15;382(Pt 3):769-81. DOI:10.1042/BJ20040892 |
- Shoseyov O, Shani Z, and Levy I. Carbohydrate binding modules: biochemical properties and novel applications. Microbiol Mol Biol Rev. 2006 Jun;70(2):283-95. DOI:10.1128/MMBR.00028-05 |
- Hashimoto H. Recent structural studies of carbohydrate-binding modules. Cell Mol Life Sci. 2006 Dec;63(24):2954-67. DOI:10.1007/s00018-006-6195-3 |
- Guillén D, Sánchez S, and Rodríguez-Sanoja R. Carbohydrate-binding domains: multiplicity of biological roles. Appl Microbiol Biotechnol. 2010 Feb;85(5):1241-9. DOI:10.1007/s00253-009-2331-y |
- Ficko-Blean E and Boraston AB. Insights into the recognition of the human glycome by microbial carbohydrate-binding modules. Curr Opin Struct Biol. 2012 Oct;22(5):570-7. DOI:10.1016/j.sbi.2012.07.009 |
- Gilbert HJ, Knox JP, and Boraston AB. Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules. Curr Opin Struct Biol. 2013 Oct;23(5):669-77. DOI:10.1016/j.sbi.2013.05.005 |
- Armenta S, Moreno-Mendieta S, Sánchez-Cuapio Z, Sánchez S, and Rodríguez-Sanoja R. Advances in molecular engineering of carbohydrate-binding modules. Proteins. 2017 Sep;85(9):1602-1617. DOI:10.1002/prot.25327 |