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Welcome to CAZypedia!
The Encyclopedia of Carbohydrate-Active Enzymes.
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CAZypedia has been initiated as a community-driven resource to assemble a comprehensive encyclopedia of the "CAZymes," the carbohydrate-active enzymes and associated carbohydrate-binding modules involved in the synthesis and degradation of complex carbohydrates. CAZypedia is inspired by, and closely connected with, the actively curated CAZy Database.
It's probably fair to say that CAZypedians are, like our friends at the CAZy DB, a group of "biocurators."


CAZypedia initially focussed on the Glycoside Hydrolase Families defined in the CAZy Database, and we continue to strive for complete coverage of this diverse class of enzymes. Other catabolic and anabolic CAZymes (e.g. Polysaccharide Lyases and Glycosyltransferases), as well as Auxiliary redox enzymes and non-catalytic Carbohydrate Binding Modules, continue to be incorporated as interest and engagement from the scientific community grows. In addition, there is a Lexicon of terms relevant to CAZymes and carbohydrate chemistry.
These and other aspects of CAZypedia's content can be accessed through the menus on the left side of each page.

How CAZypedia works

CAZypedia is built on authoring and editing principles similar to those of other expert-based online encyclopedias (cf. Citizendium, Scholarpedia). All contributors to CAZypedia, from the Authors to the Board of Curators, are experts in the field. Transparency is achieved through the use of contributors' real names and published biographies in CAZypedia. Individual entries in CAZypedia are managed by Responsible Curators, who are responsible for selecting expert Authors and coordinating author contributions on individual pages. Selection of Responsible Curators, based on their specialist expertise and ability to participate in the active maintenance of entry content, is handled by the Senior Curators.
More information on CAZypedia's content and editorial policies is available here.
A short lecture and a set of slides presenting CAZypedia are freely available here.


If you would like to contact the Board of Curators to get involved with CAZypedia or suggest an improvement, please use this form.

Latest news

11 September 2015: Let's hear it for the transglycosylases!: Today, Authors Ramon Hurtado-Guerrero and Thierry Fontaine, together with Responsible Curator Bernard Henrissat, completed the Glycoside Hydrolase Family 72 page. GH72 is a small but important family of beta(1-3)-glucan transglycosylases that function to remodel the cell wall during the growth of yeast and other fungi. Predominant or strict transglycosylases are relatively rare in GH families, with other notable examples coming from GH13, GH16, GH31, GH70, and GH77. Read more about GH72 and what makes transglycosylases so interesting here in CAZypedia!

6 August 2015: Live from the Cellulase/CAZyme GRC: CAZypedia marches on with the completion of the Polysaccharide Lyase Family 1 today by Responsible Curator and Author Richard Pickersgill, with additional editing by Polysaccharide Lyase Families coordinator Wade Abbott. PL1 contains pectate lyases from microbes and plants, which are key enzymes in plant cell wall remodelling/break-down. The solution of the crystal structure of a pectate lyase C from the plant pathogen Erwinia chrysanthemi was the first to reveal the parallel beta-helix as a novel protein fold that is now known to serve as the scaffold of other pectinolytic enzymes, including pectin hydrolases (GH28) and pectin methylesterases (CE8). Read more about the discovery of pectate lyases and the enzymology and crystallography of PL1 here.

28 July 2015: 100 GH FAMILIES!!! We are extremely pleased to announce that CAZypedia has reached the key milestone of 100 Curator Approved Glycoside Hydrolase Family pages today, thanks to the completion of the Glycoside Hydrolase Family 12 page by Gerlind Sulzenbacher. GH12 is one of the classic "cellulase" families (formerly known as cellulase family H) defined early in the history of the CAZy classification; GH12 is now known to comprise both microbial endo-glucanases and endo-xyloglucanases. The completion of this page is especially timely in advance of the upcoming 2015 GRC on Cellulosomes, Cellulases & Other Carbohydrate Modifying Enzymes, happening next week. Gerlind performed the seminal crystallography in this family (under the mentorship of Gideon Davies), and we would especially like to thank her for producing an excellent summary and series of figures for the "Three-dimensional structures" section.

The Board of Curators would also like to take the opportunity of this key milestone to express our sincere gratitude to our many expert Contributors for their time and dedication to building CAZypedia as a community-based resource over the past 8 years. In addition to the 100 Curator Approved GH pages, CAZypedia also currently contains 5 PL Family pages, 2 AA Family pages, 2 GT Family pages, 10 CBM Family pages, and 22 Lexicon pages!

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CAZypedia is dedicated to the late Prof. Bruce Stone, whose enthusiasm to create a comprehensive encyclopedia of carbohydrate-active enzymes was essential in the genesis of this project.
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