CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
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Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.
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== Structural Features == | == Structural Features == | ||
| − | ''Content should include a description of:'' | + | ''Content in this section should include, in paragraph form, a description of:'' |
* '''Fold:''' Structural fold (beta trefoil, beta sandwich, etc.) | * '''Fold:''' Structural fold (beta trefoil, beta sandwich, etc.) | ||
* '''Type:''' Include here Type A, B, or C and properties | * '''Type:''' Include here Type A, B, or C and properties | ||
| Line 21: | Line 21: | ||
== Functionalities == | == Functionalities == | ||
| − | + | ''Content in this section should include, in paragraph form, a description of:'' | |
| − | Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate. | + | * '''Functional role of CBM:''' Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate. |
| − | + | * '''Most Common Associated Modules:''' 1. Glycoside Hydrolase Activity; 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.) | |
| − | 1. Glycoside Hydrolase Activity | + | * '''Novel Applications:''' Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc. |
| − | |||
| − | 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.) | ||
| − | |||
| − | Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc. | ||
== Family Firsts == | == Family Firsts == | ||
| − | + | ;First Identified | |
| − | + | :Insert archetype here, possibly including ''very brief'' synopsis. | |
| − | + | ;First Structural Characterization | |
| − | + | :Insert archetype here, possibly including ''very brief'' synopsis. | |
== References == | == References == | ||
Revision as of 11:03, 7 May 2013
{{UnderConstruction}}
- Author: ^^^Alicia Lammerts van Bueren^^^
- Responsible Curator: ^^^Alicia Lammerts van Bueren^^^
Page content has yet to be added. In the meantime, please see these references for an essential introduction to the CAZy classification system: [1, 2]. CBMs, in particular, have been extensively reviewed [3, 4, 5, 6].
Ligand specificities
Mention here all major natural ligand specificities that are found within a given family (also plant or mammalian origin). Certain linkages and promiscuity would also be mentioned here if biologically relevant.
Structural Features
Content in this section should include, in paragraph form, a description of:
- Fold: Structural fold (beta trefoil, beta sandwich, etc.)
- Type: Include here Type A, B, or C and properties
- Features of ligand binding: Describe CBM binding pocket location (Side or apex) important residues for binding (W, Y, F, subsites), interact with reducing end, non-reducing end, planar surface or within polysaccharide chains. Include examples pdb codes. Metal ion dependent. Etc.
Functionalities
Content in this section should include, in paragraph form, a description of:
- Functional role of CBM: Describe common functional roles such as targeting, disruptive, anchoring, proximity/position on substrate.
- Most Common Associated Modules: 1. Glycoside Hydrolase Activity; 2. Additional Associated Modules (other CBM, FNIII, cohesin, dockerins, expansins, etc.)
- Novel Applications: Include here if CBM has been used to modify another enzyme, or if a CBM was used to label plant/mammalian tissues? Etc.
Family Firsts
- First Identified
- Insert archetype here, possibly including very brief synopsis.
- First Structural Characterization
- Insert archetype here, possibly including very brief synopsis.
References
-
Davies, G.J. and Sinnott, M.L. (2008) Sorting the diverse: the sequence-based classifications of carbohydrate-active enzymes. Biochem. J. (BJ Classic Paper, online only). DOI: 10.1042/BJ20080382
- Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, and Henrissat B. (2009). The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37(Database issue):D233-8. DOI:10.1093/nar/gkn663 |
- Boraston AB, Bolam DN, Gilbert HJ, and Davies GJ. (2004). Carbohydrate-binding modules: fine-tuning polysaccharide recognition. Biochem J. 2004;382(Pt 3):769-81. DOI:10.1042/BJ20040892 |
- Hashimoto H (2006). Recent structural studies of carbohydrate-binding modules. Cell Mol Life Sci. 2006;63(24):2954-67. DOI:10.1007/s00018-006-6195-3 |
- Shoseyov O, Shani Z, and Levy I. (2006). Carbohydrate binding modules: biochemical properties and novel applications. Microbiol Mol Biol Rev. 2006;70(2):283-95. DOI:10.1128/MMBR.00028-05 |
- Guillén D, Sánchez S, and Rodríguez-Sanoja R. (2010). Carbohydrate-binding domains: multiplicity of biological roles. Appl Microbiol Biotechnol. 2010;85(5):1241-9. DOI:10.1007/s00253-009-2331-y |
[[Category:Carbohydrate Binding Module Families|CBMnnn]]