CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
*
Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.

Difference between revisions of "Template:News"

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'''19 March 2015:''' ''Closing-in on 100:'' ''CAZypedia'' is on the way to an important milestone, our 100th [[Curator Approved]] [[Glycoside Hydrolase Families|Glycoside Hydrolase Family]] page.  Thanks go to our colleagues '''[[User:Tomomi Sumida|Tomomi Sumida]]''', who completed the '''[[Glycoside Hydrolase Family 123]]''' page on March 17, and '''[[User:Wataru Saburi|Wataru Saburi]]''' and '''[[User:Haruhide Mori|Haruhide Mori]]''', who completed the '''[[Glycoside Hydrolase Family 130]]''' page on March 18.  Members of these two [[Glycoside Hydrolase Families|GH families]] represent very distinct structures, specificities mechanisms, which you can learn more about on their individual pages.  The high GH family numbers of these two groups reflect their comparatively recent addition to the [http://www.cazy.org/Glycoside-Hydrolases.html CAZy Database] and highlight the continuing evolution of the field through the discovery of new CAZymes.
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.  
 
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'''23 February 2015:''' ''The sites that bind:'' '''[[User:Birte Svensson|Birte Svensson]]''' and '''[[User:Darrell Cockburn|Darrell Cockburn]]''' have completed the '''[[Surface Binding Site]]''' page within the ''CAZypedia'' [[Lexicon]].  Surface binding sites are substrate-binding regions found on the catalytic domain of carbohydrate-active enzymes and appear to play complementary roles to carbohydrate-binding modules in facilitating the action of polysaccharide-degrading glycoside hydrolases. ''Read more about these intriguing features and their distribution among CAZymes [[Surface Binding Site|here]].''
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'''11 February 2024:''' ''A "BLAST" from the past, with a fresh update.'' [[Author]] '''[[User:Eduardo Moreno Prieto|Eduardo Moreno Prieto]]''' composed a new page on '''[[Glycoside Hydrolase Family 119]]''',a family of bacterial amylases, which was [[Curator Approved]] by '''[[User:Stefan Janecek|Stefan Janecek]]''' and '''[[User:Bernard Henrissat|Bernard Henrissat]]''' today.  The first member of '''[[GH119]]''' was characterized in 2006, and through sequence analysis with [[GH57]] members, [[User:Stefan Janecek|Janeček]] and Kuchtová predicted the active-site residues in 2012.  Over a decade later, '''[[User:Eduardo Moreno Prieto|Eduardo]]''', '''[[User:Bernard Henrissat|Bernard]]''', and colleagues finally provided critical experimental support for these predictions.  ''Learn more about this history, and especially the relationship between '''[[GH119]]''' and '''[[GH57]]''', in CAZypedia.''
 
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'''20 February 2015:''' ''One for the Gals:'' '''[[User:Harry Gilbert|Harry Gilbert]]''' has given the '''[[Carbohydrate Binding Module Family 62]]''' page, which was authored by '''[[User:Cedric Montanier|Cedric Montanier]]''', [[Curator Approved]] status today.  Functional and structural characterization of the archetypal '''[[CBM62]]''' member from a ''Clostridium thermocellum'' xylanase revealed a strong affinity for galactose residues of either anomeric configuration on plant polysaccharides.  Although the precise roles of this and other '''[[CBM62]]''' members remains somewhat ambiguous, it is clear that these modules are relevant to the targeting of enzymes to the composite plant cell wall.  ''Read more about the work of the all-star team that put [[CBM62]] on the map (of CAZy families), [[Carbohydrate Binding Module Family 62|here]].''
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'''3 February 2024:''' ''A new family of beta-1,2-glucan-cyclizing enzymes.'' A page on the (currently) newest GH family, '''[[Glycoside Hydrolase Family 189]]''', was completed today by [[Author]]s '''[[User:Tomoko Masaike|Tomoko Masaike]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' ([[User:Masahiro Nakajima|Masahiro Nakajima]] is the [[Responsible Curator]]). '''[[GH189]]''' is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules.  The discovery of '''[[GH189]]''' builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in [[GH144]] and [[GH162]], which share a common protein fold with '''[[GH189]]''', but have distinct mechansims. ''Check out the '''[[GH189]]''', [[GH144]], and [[GH162]] pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!''
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'''19 January 2015:'''  ''Still in the high 70's today:'' '''[[User:Zui Fujimoto|Zui Fujimoto]]''' brought the '''[[Glycoside Hydrolase Family 78]]''' page up to [[Curator Approved]] status today, making it ''CAZypedia's'' 97th approved GH page. '''[[GH78]]''' is a family of archaeal, bacterial, and fungal alpha-L-rhamnosidases that cleave diverse flavonoid glycosides, polysaccharides, glycoproteins, and glycolipids from plants.  ''Read more on these ecologically relevant enzymes [[Glycoside Hydrolase Family 78|here]].''
 
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'''7 January 2015:''' ''Love your guts:'' ''CAZypedia'' is ringing in the new year with a new '''[[Glycoside Hydrolase Family 76]]''' page by '''[[User:Spencer Williams|Spencer Williams]]'''.  '''[[GH76]]''' contains endo-acting α-mannanases, including members from the human gut bacterium ''Bacteroides thetaiotaomicron'' that enable us to degrade yeast mannans in our diet.  A very recent publication in ''Nature'', notably involving ''CAZypedia'' contributors '''[[User:Michael Suits|Michael Suits]]''', '''[[User:Al Boraston|Al Boraston]]''', '''[[User:Spencer Williams|Spencer Williams]]''', '''[[User:Gideon Davies|Gideon Davies]]''', '''[[User:Wade Abbott|Wade Abbott]]''', and '''[[User:Harry Gilbert|Harry Gilbert]]''', has recently shed new light on the structure, mechanism, and biological function of these enzymes.  ''Read more [[Glycoside Hydrolase Family 76|here]]!''
 
 
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Latest revision as of 08:08, 2 May 2024

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.

11 February 2024: A "BLAST" from the past, with a fresh update. Author Eduardo Moreno Prieto composed a new page on Glycoside Hydrolase Family 119,a family of bacterial amylases, which was Curator Approved by Stefan Janecek and Bernard Henrissat today. The first member of GH119 was characterized in 2006, and through sequence analysis with GH57 members, Janeček and Kuchtová predicted the active-site residues in 2012. Over a decade later, Eduardo, Bernard, and colleagues finally provided critical experimental support for these predictions. Learn more about this history, and especially the relationship between GH119 and GH57, in CAZypedia.

3 February 2024: A new family of beta-1,2-glucan-cyclizing enzymes. A page on the (currently) newest GH family, Glycoside Hydrolase Family 189, was completed today by Authors Tomoko Masaike, Masahiro Nakajima, and Nobukiyo Tanaka (Masahiro Nakajima is the Responsible Curator). GH189 is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules. The discovery of GH189 builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in GH144 and GH162, which share a common protein fold with GH189, but have distinct mechansims. Check out the GH189, GH144, and GH162 pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!

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