CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
*
Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.

Difference between revisions of "Template:News"

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'''November 23, 2018:''' ''Welcome to the CAZypedia fold [[CBM49]]!'' The crystalline cellulose-binding [[CBM49]] CAZypedia page was authored by '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' and '''[[User:Elizabeth Ficko-Blean|Elizabeth Ficko-Blean]]'''.  '''[[User:Breeanna Urbanowicz|Breeanna Urbanowicz]]''' also acted as responsible curator.  There is experimental evidence that rice[[CBM49]] is cleaved post-translationally in vivo which probably plays an important role in plant growth. Find out more about the interesting family 49 CBMs '''[[CBM49|here]]'''.
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'''2 May 2024:''' ''CBDs I to X... A major milestone!'' '''CBM families 1 to 10 are now complete!''' These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective ''CAZypedia'' pages: '''[[CBM1]], [[CBM2]], [[CBM3]], [[CBM4]], [[CBM5]], [[CBM6]], [[CBM7]], [[CBM8]], [[CBM9]], and [[CBM10]]'''.  
 
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'''October 11, 2018:''' ''Fall ushers in a new CAZypedia CBM family page.''  The chitin-binding and lytic polysaccharide monooxygenase associated [[CBM73]] family is described in detail.  '''[[User:Zarah Forsberg|Zarah Forsberg]]''' authored the page and '''[[User:Gustav Vaaje-Kolstad|Gustav Vaaje-Kolstad]]''' acted as responsible curator. Learn more about the [[CBM73]] family on its CAZypedia [[CBM73|page]].  
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'''11 February 2024:''' ''A "BLAST" from the past, with a fresh update.'' [[Author]] '''[[User:Eduardo Moreno Prieto|Eduardo Moreno Prieto]]''' composed a new page on '''[[Glycoside Hydrolase Family 119]]''',a family of bacterial amylases, which was [[Curator Approved]] by '''[[User:Stefan Janecek|Stefan Janecek]]''' and '''[[User:Bernard Henrissat|Bernard Henrissat]]''' today. The first member of '''[[GH119]]''' was characterized in 2006, and through sequence analysis with [[GH57]] members, [[User:Stefan Janecek|Janeček]] and Kuchtová predicted the active-site residues in 2012Over a decade later, '''[[User:Eduardo Moreno Prieto|Eduardo]]''', '''[[User:Bernard Henrissat|Bernard]]''', and colleagues finally provided critical experimental support for these predictions. ''Learn more about this history, and especially the relationship between '''[[GH119]]''' and '''[[GH57]]''', in CAZypedia.''
 
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'''September 24, 2018:''' ''Revenge of the Ruminococci Part Deux.'' Two more CBM families from Ruminococcal bacteria are ready for reading.  The [[CBM79]] and [[CBM80]] CAZypedia pages were authored by '''[[User:Immacolata Venditto|Immacolata Venditto]]''' and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. These CBMs are important for enzyme targeting but also for targeting the entire cellulosome complex to substrate. Information on the [[CBM79]] and [[CBM80]] families can be found on their respective CAZypedia pages.
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'''3 February 2024:''' ''A new family of beta-1,2-glucan-cyclizing enzymes.'' A page on the (currently) newest GH family, '''[[Glycoside Hydrolase Family 189]]''', was completed today by [[Author]]s '''[[User:Tomoko Masaike|Tomoko Masaike]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' ([[User:Masahiro Nakajima|Masahiro Nakajima]] is the [[Responsible Curator]]). '''[[GH189]]''' is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules.  The discovery of '''[[GH189]]''' builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in [[GH144]] and [[GH162]], which share a common protein fold with '''[[GH189]]''', but have distinct mechansims. ''Check out the '''[[GH189]]''', [[GH144]], and [[GH162]] pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!''
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'''July 3, 2018:''' ''Revenge of the Ruminococci.''  Three CBM families containing characterized CBM members from Ruminococcal bacteria are now on-line in CAZypedia; two of these families contain uniquely Ruminococcal CBMs.  '''[[User:Ana Luis|Ana Luis]]''' authored the pages (in one fell swoop) and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. Descriptions of families '''[[CBM75]]''', '''[[CBM76]]''' and '''[[CBM77]]''' can be found on their respective CAZypedia pages.
 
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'''June 4, 2018:'''  ''When two worlds collide.'' The '''[[CBM81]]''' family has an interesting binding mechanism, mixing characteristics of both [[Carbohydrate-binding_modules#Types|type A]] and [[Carbohydrate-binding_modules#Types|type B]] CBMs.  The binding is enthalpically driven to soluble ligands, so by definition this is a [[Carbohydrate-binding_modules#Types|type B]] interaction;  however, the CBM binding face resembles the flat face of [[Carbohydrate-binding_modules#Types|type A]] (crystalline-polysaccharide binding) CBMs.  '''[[User: Marcelo Liberato|Marcelo Liberato]]''' [[author]]ed the [[CBM81]] page and '''[[User: Fabio Squina|Fabio Squina]]''' acted as the [[Responsible Curator]].  Find out more about the unusual family 81 CBMs '''[[CBM81|here]]'''.
 
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'''25 May 2018:''' ''The almost exclusive expansin associated [[CBM63]] family is on-line.'' An interesting function is described as a bacterial [[CBM63]] targets expansin to biomechanical hotspots in the ''Arabidopsis'' cell wall, where cell wall loosening occurs. The page was authored by '''[[User: Will Chase|Will Chase]]''' and '''[[User: Daniel Cosgrove|Daniel Cosgrove]]''' with '''[[User: Daniel Cosgrove|Daniel Cosgrove]]''' acting as responsible curator.  Learn more about this expansin family CBM [[CBM63|here]].
 
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'''4 May 2018:''' ''CAZypedia's first non-LPMO Auxiliary Activity Family page!''  Today [[Responsible Curator]] '''[[User:Roland Ludwig|Roland Ludwig]]''' [[Curator Approved|approved]] '''[[User:Daniel Kracher|Daniel Kracher's]]''' and his expansive '''[[Auxiliary Activity Family 3]]''' page. '''[[AA3]]''' comprises a number of FAD-dependent redox enzymes including cellobiose dehydrogenase, aryl alcohol oxidase/dehydrogenases, glucose oxidases and glucose dehydrogenases, pyranose dehydrogenase, alcohol oxidase, and pyranose oxidase across four subfamilies. '''''[[User:Roland Ludwig|Roland]]''' and '''[[User:Daniel Kracher|Daniel]]''' have done a monumental job in succinctly capturing the diversity of this family, which you can read about [[Auxiliary Activity Family 3|here]].''  
 
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'''2 May 2018:''' ''The [[CBM65]] page has been added to the CAZypedia fold.'' This is a small CAZy family with  two currently characterized members from an anaerobic cellulolytic ruminal bacterium.  The two [[CBM65]] members bind various beta-glucans and play an important role in enhancing enzymatic activity on substrate. The page was authored by '''[[User:Ana Luis|Ana Luis]]''' and '''[[User:Harry Gilbert|Harry Gilbert]]''' acted as responsible curator. ''Learn more about this CBM family [[CBM65|here]].''
 
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'''1 March 2018:''' The shortest month of the year saw four '''[[CBM]]''' families reach '''[[Curator Approved]]''' status, including two early members.  '''[[User:Harry Gilbert|Harry Gilbert]]''' with input from '''[[User:Ed Bayer|Ed Bayer]]''', who also acted as '''[[Responsible Curator]]''', authored the cellulose-binding '''[[CBM3]]''' page'''[[User:Harry Gilbert|Harry Gilbert]]''' and '''[[User:Claire Dumon|Claire Dumon]]''' both contributed to the xylan and glucan-binding '''[[CBM4]]''' page.  The xylan-binding '''[[CBM22]]''' page was taken on by '''[[User:Harry Gilbert|Harry Gilbert]]''' solo.  Finally, the cellulose-binding '''[[CBM78]]''' family was authored by '''[[User:Immacolata Venditto|Immacolata Venditto]]''', with '''[[User:Harry Gilbert|Harry Gilbert]]''' acting as '''[[Responsible Curator]]'''.  ''Learn more about each of these families on [[Carbohydrate Binding Module Families|their respective pages]].''
 
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'''15 February 2018:''' ''More on pectin, and also arabinan:''  '''[[User:Jonathon Briggs|Jonathon Briggs]]''' recently completed the '''[[Glycoside Hydrolase Family 147]]''' and '''[[Glycoside Hydrolase Family 146]]''' pages, which are involved in the utilization of pectin and galactan, respectively, by human gut Bacteroidetes.  Both pages were upgraded to [[Curator Approved]] status today by [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]'''.  ''Learn more about these newly described families at [[GH146]] and [[GH147]].''
 
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'''13 February 2018:''' ''The intricacies of pectin deconstruction:'' Rhamnogalacturonan II (RGII) represents the most structurally complex plant cell wall polysaccharide currently known, the complete saccharification of which requires a battery of CAZymes.  Under the guidance of [[Responsible Curator]] '''[[User:Harry Gilbert|Harry Gilbert]]''', four new GH pages related to RGII deconstruction were [[Curator Approved]] today. Special thanks go to [[Author]]s '''[[User:Ana Luis|Ana Luis]]''' ('''[[GH106]]''', '''[[GH139]]''', and '''[[GH141]]''') and '''[[User:Didier Ndeh|Didier Ndeh]]''' ('''[[GH138]]''') for their hard work in putting these pages together. ''Learn more about the individual, specific contributions of each of these families (three of which have been recently uncovered) to microbial RGII utilization on their respective pages.''
 
 
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Latest revision as of 08:08, 2 May 2024

2 May 2024: CBDs I to X... A major milestone! CBM families 1 to 10 are now complete! These are the old CBD (cellulose-binding domain) families, which used to have roman numerals as part of their nomenclature. A special thank you to all the authors and responsible curators who have contributed to this major milestone. Go have a peek at each of these old school families on their respective CAZypedia pages: CBM1, CBM2, CBM3, CBM4, CBM5, CBM6, CBM7, CBM8, CBM9, and CBM10.


11 February 2024: A "BLAST" from the past, with a fresh update. Author Eduardo Moreno Prieto composed a new page on Glycoside Hydrolase Family 119,a family of bacterial amylases, which was Curator Approved by Stefan Janecek and Bernard Henrissat today. The first member of GH119 was characterized in 2006, and through sequence analysis with GH57 members, Janeček and Kuchtová predicted the active-site residues in 2012. Over a decade later, Eduardo, Bernard, and colleagues finally provided critical experimental support for these predictions. Learn more about this history, and especially the relationship between GH119 and GH57, in CAZypedia.


3 February 2024: A new family of beta-1,2-glucan-cyclizing enzymes. A page on the (currently) newest GH family, Glycoside Hydrolase Family 189, was completed today by Authors Tomoko Masaike, Masahiro Nakajima, and Nobukiyo Tanaka (Masahiro Nakajima is the Responsible Curator). GH189 is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules. The discovery of GH189 builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in GH144 and GH162, which share a common protein fold with GH189, but have distinct mechansims. Check out the GH189, GH144, and GH162 pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!