CAZypedia needs your help! We have many unassigned GH, PL, CE, AA, GT, and CBM pages in need of Authors and Responsible Curators.
Scientists at all career stages, including students, are welcome to contribute to CAZypedia. Read more here, and in the 10th anniversary article in Glycobiology.
New to the CAZy classification? Read this first.
*
Consider attending the 15th Carbohydrate Bioengineering Meeting in Ghent, 5-8 May 2024.

Difference between revisions of "Template:News"

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'''16 August 2023:''' 'An oldie but a goodie.' The ''[[CBM9|CAZypedia]]'' page for '''[[CBM9]]''', one of the original founding top 10 CBM families, has been completed by '''[[User:Johan Larsbrink|Johan Larsbrink]]''' who multitasked as both author and responsible curator. These [[CBM9]]s are often found in ultra-multimodular xylan deconstructing bacterial enzymes and their cellulose-binding functionality has been exploited for use as affinity tags in recombinant protein purifications. ''Read more on this historically important CBM family '''[[CBM9|here]]'''!''  
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'''11 February 2024:''' ''A "BLAST" from the past, with a fresh update.'' [[Author]] '''[[User:Eduardo Moreno Prieto|Eduardo Moreno Prieto]]''' composed a new page on '''[[Glycoside Hydrolase Family 119]]''',a family of bacterial amylases, which was [[Curator Approved]] by '''[[User:Stefan Janecek|Stefan Janecek]]''' and '''[[User:Bernard Henrissat|Bernard Henrissat]]''' today. The first member of '''[[GH119]]''' was characterized in 2006, and through sequence analysis with [[GH57]] members, [[User:Stefan Janecek|Janeček]] and Kuchtová predicted the active-site residues in 2012.  Over a decade later, '''[[User:Eduardo Moreno Prieto|Eduardo]]''', '''[[User:Bernard Henrissat|Bernard]]''', and colleagues finally provided critical experimental support for these predictions. ''Learn more about this history, and especially the relationship between '''[[GH119]]''' and '''[[GH57]]''', in CAZypedia.''
 
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'''25 June 2023:''' ''Another one from the [https://en.wikipedia.org/wiki/Capybara capybara gut].'' We're pleased to announce that the '''[[Glycoside Hydrolase Family 173]]''' page, written by [[Author]]s '''[[User:Clelton Santos|Clelton Aparecido dos Santos]]''' and '''[[User:Gabriela Persinoti|Gabriela Felix Persinoti]]''' was [[Curator Approved]] by '''[[User:Mario Murakami|Mario Murakami]]''' today.  This new family of beta-galactosidases was created through the same study of the capybara gut metagenome by the [[User:Mario Murakami|Murakami group]] that led to the creation of family [[CBM89]] (''see the June 22nd [[News]] item'').   '''[[GH173]]''' appears to be distantly related to [[GH5]] and [[GH30]] in [[Clan]] GH-A, yet there remain many unknowns about this family and its founding member - ''read more  [[GH173|here]]!''
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'''3 February 2024:''' ''A new family of beta-1,2-glucan-cyclizing enzymes.'' A page on the (currently) newest GH family, '''[[Glycoside Hydrolase Family 189]]''', was completed today by [[Author]]s '''[[User:Tomoko Masaike|Tomoko Masaike]]''', '''[[User:Masahiro Nakajima|Masahiro Nakajima]]''', and '''[[User:Nobukiyo Tanaka|Nobukiyo Tanaka]]''' ([[User:Masahiro Nakajima|Masahiro Nakajima]] is the [[Responsible Curator]]). '''[[GH189]]''' is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules. The discovery of '''[[GH189]]''' builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in [[GH144]] and [[GH162]], which share a common protein fold with '''[[GH189]]''', but have distinct mechansims. ''Check out the '''[[GH189]]''', [[GH144]], and [[GH162]] pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!''
 
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'''4 January 2024:''' ''CBM99, CBM100 and CBM101 in one fell swoop!'' Three new CBM families have been added to the ''CAZypedia'' repertoire. Though the families differ in their glycan targets, they share the interesting function of binding to highly complex sulfated marine polymers. '''[[User:Yaoguang Chang|Yaoguang Chang]]''' acted as [[Responsible Curator]] on all three pages. '''[[User:Xuanwei Mei|Xuanwei Mei]]''' [[author]]ed the [[CBM99]] and [[CBM101]] red algal specific pages and '''[[User:Guanchen Liu|Guanchen Liu]]''' authored the [[CBM100]] glycosaminoglycan specific page. ''Learn more about [[CBM99]], [[CBM100]] and [[CBM101]] on their respective pages!''  
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'''23 June 2023:''' ''Human milk oligosaccharide metabolism.'' [[Author]] '''[[User:Chihaya Yamada|Chihaya Yamada]]''' and [[Responsible Curator]] '''[[User:Shinya Fushinobu|Shinya Fushinobu]]''' upgraded the '''[[Glycoside Hydrolase Family 136]]''' page to [[Curator Approved]] status today.  '''[[GH136]]''' is a family of bacterial lacto-''N''-biosidases that release lacto-''N''-biose I and lactose from lacto-N-tetraose, the main component of human milk oligosaccharides.  These enzymes have a comparatively rare right-handed beta helix fold that more typical of pectin-active [[PL]]s and [[GH]]s. ''Read more about these interesting enzymes and their role in the human gut microbiota [[GH136|here]]!''
 
  
 
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'''22 June 2023:''' ''These [[CBM89]]s are sizeable!'' The recently discovered xylan-binding CBM89 family, originating from the capybara gut microbiota, is described by [[Author]]s: '''[[User:Mariana Morais|Mariana Abrahão Bueno de Morais]]''' and '''[[User:Gabriela Persinoti|Gabriela Felix Persinoti]]'''. '''[[User:Mario Murakami|Mario Murakami]]''' acted as  [[Responsible Curator]] on the [[CBM89|page]].  [[CBM89]]s are 600 - 1000 amino acids long which puts them in the upper echelons of CBM sizes - just as the capybara is to the rodent order.  You can check out the write up on these unusually large CBMs on their '''[[CBM89]] ''[[CBM89|CAZypedia]]'' [[CBM89|page]]'''.
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'''4 January 2024:''' ''More "Fun" from the sea.'' Today, '''[[User:Yaoguang Chang|Yaoguang Chang]]''' [[Curator Approved]] the '''[[Glycoside Hydrolase Family 187]]''' page [[Author]]ed by '''[[User:Jingjing Shen|Jingjing Shen]]'''. The founding member of '''[[GH187]]''' is the alpha-1,3-L-fucanase ("Fun187A") the marine bacterium ''Wenyingzhuangia aestuarii'', which recognizes a specific sulfated motif in sea cucumber fucans.  '''[[GH187]]''' is a small family (<50 members) and there remains much to elucidate regarding catalytic mechanism and enzyme structure. Interest in CAZymes active on marine biomass continues to grow, and we welcome this expansion in ''CAZypedia''. ''Learn more about '''[[GH187|GH187 here!]]'''''
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'''26 May 2023:''' ''A new page for a nacent family.'' [[Author]] '''[[User:Guanchen Liu|Guanchen Liu]]''' and [[Responsible Curator]] '''[[User:Yaoguang Chang|Yaoguang Chang]]''' completed the '''[[Glycoside Hydrolase Family 174]]''' page today. '''[[GH174]]''' is a recently established family of (so far) bacterial alpha-1,3-L-fucanases, which was reported by [[User:Guanchen Liu|Guanchen Liu]], [[User:Yaoguang Chang|Yaoguang Chang]] and colleagues in April, following the characterization of a representative from the marine bacterium ''Wenyingzhuangia aestuarii''.  Notably, this enzyme appears to prefer sulfated fucans, and generates a highly sulfated tetrasaccharide as the main hydrolysis product.  ''Read more about this interesting enzyme and family [[GH174|here]]!''
 
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'''13 April 2023:''' ''The champagne is on ice!'' We are ecstatic to report that we’ve hit 50 [[Curator Approved]] ''CAZypedia'' [[Carbohydrate Binding Module Families|CBM pages]]!
 
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The '''[[CBM92]]''' and the '''[[CBM94]]''' page were finished within under 3 hours of one another. Congratulations to the contributors for both of the pages: new ''CAZypedia'' contibutors '''[[User:Xuanwei Mei|Xuanwei Mei]]''' and  '''[[User:Yaoguang Chang|Yaoguang Chang]]''' for the [[CBM92]] page and longtime ''CAZypedia'' contributor '''[[User:Takatsugu Miyazaki|Takatsugu Miyazaki]]''' for the [[CBM94]] page.
 
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Next stop: 100 [[Curator Approved]] [[Carbohydrate Binding Module Families|CBM pages]] (this may take a little while).
 
 
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'''13 April 2023, 00:20:''' ''CBM92 is red hot!'' [[CBM92]] is one of the newer families of CBMs and it has a red hot preference for the red algal extracellular matrix polysaccharide carrageenan, a complex sulfated galactan. Author '''[[User:Xuanwei Mei|Xuanwei Mei]]''' describes the novel carrageenan-binding capacities of the biochemically characterized [[CBM92]] which can be found appended to a kappa-carrageenase produced by the marine bacterium ''Wenyingzhuangia aestuarii''.  '''[[User:Yaoguang Chang|Yaoguang Chang]]''' acted as responsible curator on the page. ''Head on over to the '''[[CBM92]]''' page to learn more about this red hot CBM family!''
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'''17 December 2023:''' ''Redox-assisted glycoside hydrolysis, redux.'' Just before the turn of the new year, '''[[User:Spencer Williams|Spencer Williams]]''' completed the '''[[Glycoside Hydrolase Family 188]]''' page. '''[[GH188]]''' is the latest representative of a growing number of [[Glycoside hydrolases|Glycoside Hydrolase]] families, including [[GH4]], [[GH109]], [[GH177]], and [[GH179]], which use an [[NAD-dependent hydrolysis|NAD-dependent]] oxidation-elimination-addition-reduction cycle to cleave glycosidic bonds. First established ca. 20 years ago in [[GH4]], [[NAD-dependent hydrolysis|this mechanism]] is therefore distinct from the [[Glycoside_hydrolases#Mechanism|canonical Koshland mechanisms]] of glycoside hydrolysis. Notably, because oxidation occurs at C-3 of the sugar ring, followed by elimination at C-1, these enzymes can cleave both alpha- and beta-glycosides! Recently, [[User:Spencer Williams|Spencer]], [[User:Ethan Goddard-Borger|Ethan Goddard-Borger]], and [[User:Gideon Davies|Gideon Davies]] showed that [[NAD-dependent hydrolysis]] also extends to sulfoquinovoside hydrolysis by bacterial '''[[GH188]]''' members, complementing canonical sulfoquinovosidases in [[GH31]]. ''Read more about these remarkable enzymes '''[[GH188|here!]]'''''  
 
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'''12 April 2023, 21:50:''' ''CBM94, one for the books!'' Three of the [[CBM94]] eukaryotic members have recently been characterized (mouse, silkworm and human) and are described in detail on the [[CBM94]] page which has both been authored and responsibly curated by '''[[User:Takatsugu Miyazaki|Takatsugu Miyazaki]]'''. These ''N''-acetylglucosamine-specific [[CBM94]]s are found on the C-termini of ''N''-acetylglucosaminyltransferase IVa, an enzyme involved in ''N''-glycan biosynthesis.  The [[CBM94]] members play important roles in the functionality of their cognate glycosyl transferase catalytic module which is discussed in detail on the '''[[CBM94]]''' CAZypedia page. ''See more on these remarkable eukaryotic CBMs '''[[CBM94|here]]'''!''  
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'''16 August 2023:''' ''An oldie but a goodie.'' The page for '''[[CBM9]]''', one of the original founding top 10 [[Carbohydrate Binding Module Families]], has been completed by '''[[User:Johan Larsbrink|Johan Larsbrink]]''', who multitasked as both [[Author]] and [[Responsible Curator]]. '''[[CBM9]]''' members are often found in ultra-multimodular, xylan deconstructing, bacterial enzymes, and their cellulose-binding functionality has been exploited as affinity tags in recombinant protein purifications. ''Read more on this historically important [[Carbohydrate-binding modules|CBM]] family '''[[CBM9|here]]'''!''  
 
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Latest revision as of 19:00, 24 February 2024

11 February 2024: A "BLAST" from the past, with a fresh update. Author Eduardo Moreno Prieto composed a new page on Glycoside Hydrolase Family 119,a family of bacterial amylases, which was Curator Approved by Stefan Janecek and Bernard Henrissat today. The first member of GH119 was characterized in 2006, and through sequence analysis with GH57 members, Janeček and Kuchtová predicted the active-site residues in 2012. Over a decade later, Eduardo, Bernard, and colleagues finally provided critical experimental support for these predictions. Learn more about this history, and especially the relationship between GH119 and GH57, in CAZypedia.

3 February 2024: A new family of beta-1,2-glucan-cyclizing enzymes. A page on the (currently) newest GH family, Glycoside Hydrolase Family 189, was completed today by Authors Tomoko Masaike, Masahiro Nakajima, and Nobukiyo Tanaka (Masahiro Nakajima is the Responsible Curator). GH189 is a family of bacterial transglycosylases that comprise a critical domain in cyclic beta-1,2-glucan synthase (CGS), because this domain is responsible for the final cyclization step during the biosynthesis of these key effector molecules. The discovery of GH189 builds on similarly exciting work by these authors and their colleagues on beta-1,2-glucan hydrolases in GH144 and GH162, which share a common protein fold with GH189, but have distinct mechansims. Check out the GH189, GH144, and GH162 pages to learn more about this breakthrough work on beta-1,2-glucan-active enzymes!

4 January 2024: CBM99, CBM100 and CBM101 in one fell swoop! Three new CBM families have been added to the CAZypedia repertoire. Though the families differ in their glycan targets, they share the interesting function of binding to highly complex sulfated marine polymers. Yaoguang Chang acted as Responsible Curator on all three pages. Xuanwei Mei authored the CBM99 and CBM101 red algal specific pages and Guanchen Liu authored the CBM100 glycosaminoglycan specific page. Learn more about CBM99, CBM100 and CBM101 on their respective pages!

4 January 2024: More "Fun" from the sea. Today, Yaoguang Chang Curator Approved the Glycoside Hydrolase Family 187 page Authored by Jingjing Shen. The founding member of GH187 is the alpha-1,3-L-fucanase ("Fun187A") the marine bacterium Wenyingzhuangia aestuarii, which recognizes a specific sulfated motif in sea cucumber fucans. GH187 is a small family (<50 members) and there remains much to elucidate regarding catalytic mechanism and enzyme structure. Interest in CAZymes active on marine biomass continues to grow, and we welcome this expansion in CAZypedia. Learn more about GH187 here!

17 December 2023: Redox-assisted glycoside hydrolysis, redux. Just before the turn of the new year, Spencer Williams completed the Glycoside Hydrolase Family 188 page. GH188 is the latest representative of a growing number of Glycoside Hydrolase families, including GH4, GH109, GH177, and GH179, which use an NAD-dependent oxidation-elimination-addition-reduction cycle to cleave glycosidic bonds. First established ca. 20 years ago in GH4, this mechanism is therefore distinct from the canonical Koshland mechanisms of glycoside hydrolysis. Notably, because oxidation occurs at C-3 of the sugar ring, followed by elimination at C-1, these enzymes can cleave both alpha- and beta-glycosides! Recently, Spencer, Ethan Goddard-Borger, and Gideon Davies showed that NAD-dependent hydrolysis also extends to sulfoquinovoside hydrolysis by bacterial GH188 members, complementing canonical sulfoquinovosidases in GH31. Read more about these remarkable enzymes here!

16 August 2023: An oldie but a goodie. The page for CBM9, one of the original founding top 10 Carbohydrate Binding Module Families, has been completed by Johan Larsbrink, who multitasked as both Author and Responsible Curator. CBM9 members are often found in ultra-multimodular, xylan deconstructing, bacterial enzymes, and their cellulose-binding functionality has been exploited as affinity tags in recombinant protein purifications. Read more on this historically important CBM family here!

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