Glycoside Hydrolase Family 61

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This family has been deleted from the CAZy database due to reclassification following functional analysis. A specific explanation may be found below.

GH61 is a deleted family

The enzymes in this family were originally classified as a glycoside hydrolases (GH61) based on very weak endo-1,4-beta-D-glucanase activity in one family member. They are now reclassified into Auxiliary Activity Family 9 in CAZy [1]. AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of cellulose chains with oxidation of various carbons (C-1, C-4 and C-6) has been reported several times in the literature (see [2] and references therein).

References

  1. Levasseur A, Drula E, Lombard V, Coutinho PM, and Henrissat B. Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes. Biotechnol Biofuels. 2013 Mar 21;6(1):41. DOI:10.1186/1754-6834-6-41 | PubMed ID:23514094 | HubMed [Levasseur2013]
  2. Hemsworth GR, Davies GJ, and Walton PH. Recent insights into copper-containing lytic polysaccharide mono-oxygenases. Curr Opin Struct Biol. 2013 Oct;23(5):660-8. DOI:10.1016/j.sbi.2013.05.006 | PubMed ID:23769965 | HubMed [Hemsworth2013]
All Medline abstracts: PubMed | HubMed
CAZy DB links
http://www.cazy.org/AA9.html
http://www.cazy.org/GH61.html
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