User:Leila LoLeggio

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Associate Professor and Research Group leader at the Department of Chemistry, University of Copenhagen.

Short biographical sketch

Italian, born in Palermo 1971. Educated in Biochemistry at the University of Bath, during which had two inspiring introductions to the world of research in the groups of Roy Jones at the Babraham station and Angelika Noegel at the Max-Planck Institute for Biochemistry in Munich. Obtained a PhD in Crystallography from Birkbeck College, London, in 1997. In fact my PhD research was carried out at the Institute of Food Research in Reading, under the supervision of Richard Pickersgill. The project revolved around structure determination of xylanases and cellulases, and I was fortunate by being involved in the establishment of the 4/7 superfamily [1], then to become Clan GH-A[2].

I was then post-doctoral fellow in the group of Sine Larsen, at the Department of Chemistry, University of Copenhagen, first funded by a personal EMBO fellowship and later by other grants, until 2003, when I obtained a permanent position as Associate Professor in the same Department. In 2005 I became Research Group leader of the Biophysical Chemistry Group, still in the same Department. In 2013 the Biophysical Chemistry Group became part of the Bioinorganic and Biophysical Chemistry Section. Studies on the structure and function of carbohydrate active enzymes remains one of my major areas of research here in Copenhagen. My other main branch of research is on transcription factors.

I have either determined or contributed to structure determination of a number of CAZY in GH5, GH9, GH10, GH13, GH26, GH31, GH36, GH53 and PL4.

  1. Jenkins J, Lo Leggio L, Harris G, and Pickersgill R. Beta-glucosidase, beta-galactosidase, family A cellulases, family F xylanases and two barley glycanases form a superfamily of enzymes with 8-fold beta/alpha architecture and with two conserved glutamates near the carboxy-terminal ends of beta-strands four and seven. FEBS Lett. 1995 Apr 10;362(3):281-5. PubMed ID:7729513 | HubMed [Jenkins1995]
  2. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, and Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5674. PubMed ID:8643635 | HubMed [Henrissat1995]
All Medline abstracts: PubMed | HubMed
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