After receiving a B.Sc. in 2003 from the University of British Columbia in Vancouver, Canada, Matthew Macauley completed a PhD in 2010 at Simon Fraser University in Burnaby, Canada under the supervision of David Vocadlo. During his graduate studies, Matthew focused on the enzymes that regulate the O-GlcNAc modification. These studies have led to the development of potent, selective, and cell permeable inhibitors that can modulate O-GlcNAc levels in vivo. Currently, Matthew is continuing in the field of glycobiology in laboratory of Jim Paulson at The Scripps Research Institute as a PostDoc where he is investigating the roles of Siglecs in the immune system.