New to the CAZy classification? Read this first.
Want to learn more about CAZypedia? Read the CAZypedia 10th anniversary article in Glycobiology.

Main Page

From CAZypedia
Revision as of 08:39, 28 November 2016 by Harry Brumer (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Welcome to CAZypedia!
The Living Encyclopedia of Carbohydrate-Active Enzymes.
Cazypedia logo big.png


CAZypedia has been initiated as a community-driven resource to assemble a comprehensive encyclopedia of the "CAZymes," the carbohydrate-active enzymes and associated carbohydrate-binding modules involved in the synthesis and degradation of complex carbohydrates. CAZypedia is inspired by, and closely connected with, the actively curated CAZy Database. It's probably fair to say that CAZypedians are, like our friends at the CAZy DB, a group of "biocurators."
If you are new to the CAZyme classification, "Sorting the Diverse" by Professors Gideon Davies and Michael Sinnott (The Biochemist, 2008, vol. 30, part 4, pp. 26-32) provides an excellent historical introduction.


CAZypedia initially focussed on the Glycoside Hydrolase Families defined in the CAZy Database, and we continue to strive for complete coverage of this diverse class of enzymes. Other catabolic and anabolic CAZymes (e.g. Polysaccharide Lyases and Glycosyltransferases), as well as Auxiliary redox enzymes and non-catalytic Carbohydrate Binding Modules, continue to be incorporated as interest and engagement from the scientific community grows. In addition, there is a Lexicon of terms relevant to CAZymes and carbohydrate chemistry.
These and other aspects of CAZypedia's content can be accessed through the menus on the left side of each page.

How CAZypedia works

CAZypedia is built on authoring and editing principles similar to those of other expert-based online encyclopedias (cf. Citizendium, Scholarpedia). All contributors to CAZypedia, from the Authors to the Board of Curators, are experts in the field. Transparency is achieved through the use of contributors' real names and published biographies in CAZypedia. Individual entries in CAZypedia are managed by Responsible Curators, who are responsible for selecting expert Authors and coordinating author contributions on individual pages. Selection of Responsible Curators, based on their specialist expertise and ability to participate in the active maintenance of entry content, is handled by the Senior Curators.
More information on CAZypedia's content and editorial policies is available here.
A short lecture and a set of slides presenting CAZypedia are freely available here.
An article describing CAZypedia's genesis and evolution has been published in the journal Glycobiology.


If you would like to contact the Board of Curators to get involved with CAZypedia or suggest an improvement, please use this form.

Latest news

26 November 2017: CBM #1: Today, CBM pioneer Markus Linder completed the Carbohydrate Binding Module Family 1 page. CBM1 comprises the canonical fungal cellulose-binding modules (originally known as cellulose-binding domains), which were first found as stable cystine-knot-containing protein fragments released by controlled proteolysis of cellulases. The planar nature of the substrate-binding face, and linear arrangement of key aromatic residues, represent the archetype of CBMs that mediate glycosidase targeting to crystalline polysaccharides. Building on the original discovery of the modules now classified into CBM1 in Sweden, Markus Linder (then a Ph.D. student) and Tuula Teeri, working together across the Baltic Sea in Finland, were among the first to undertake structure-function studies and protein engineering of CBM1 using modern molecular techniques in the mid- to late-1990s. We're pleased to finally have this one in CAZYpedia - learn more about this seminal CBM family here.

11 October 2017: Ten years of CAZypedia! We are proud to announce the publication of a new article in Glycobiology in celebration of CAZypedia's tenth anniversary online. This article was written on behalf of all of present and future Contributors by Curators Harry Brumer and Spencer Williams, with input from a number of key individuals involved in the genesis of CAZypedia (see the Acknowledgements section for full details). A post-print version of the manuscript will be freely available from the UBC Library Open Collections, in addition to the final version on the Glycobiology website. Thanks to the hard work of a multitude of Contributors, CAZypedia is a successful example of community-driven, expert-based biocuration. We look forward to the continued development of this resource over the next ten years - and beyond!

10 September 2017: Sussing-out starch recognition in CBM58. We are excited to report that Nicole Koropatkin has completed the Carbohydrate Binding Module Family 58 page today. CBM58 constitutes a comparatively small family of CBMs found in bacteria in the phylum Bacteroidetes, including key members of the human gut microbiota such as Bacteroides thetaiotaomicron. Within these bacteria, CBM58 modules are found inserted within the GH13 catalytic module of SusG, the essential outer-membrane-bound amylase of the starch utilization system (sus). Nicole’s seminal structural biology has defined the family and provided insight into the recognition of amylose helices by CBM58 members in SusG homologs. Read more about this fascinating system here.

> older news


CAZypedia is dedicated to the late Prof. Bruce Stone, whose enthusiasm to create a comprehensive encyclopedia of carbohydrate-active enzymes was essential in the genesis of this project.
Personal tools

About CAZypedia
For contributors