Polysaccharide Lyase Family 32

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This family has been deleted from the CAZy classification. A specific explanation may be found below.

• Author: Marie-Line Garron
• Responsible Curator: Marie-Line Garron

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PL32 is a deleted family

The PL32 family was created following the functional characterization of the ORF “HMPREF1071_02769” from Bacteroides salyersiae CL02T12C01 (EIY62149.1), which showed endo-mannuronan lyase activity (EC 4.2.2.3) [1]. Shortly afterwards, the sequence was reclassified as PL_nc on the basis of structural modelling revealing that the catalytic domain was restricted to the N-terminal domain [2]. The small number of sequences and the proximity to the PL14 and PL36 families do not allow the creation of a new PL family.

References

1. Helbert W, Poulet L, Drouillard S, Mathieu S, Loiodice M, Couturier M, Lombard V, Terrapon N, Turchetto J, Vincentelli R, and Henrissat B. Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6063-6068. DOI:10.1073/pnas.1815791116 |
2. Drula E, Garron ML, Dogan S, Lombard V, Henrissat B, and Terrapon N. The carbohydrate-active enzyme database: functions and literature. Nucleic Acids Res. 2022 Jan 7;50(D1):D571-D577. DOI:10.1093/nar/gkab1045 |

CAZy DB links

https://www.cazy.org/PL32.html