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Glycoside hydrolases of family 139 family display α-2-O-methyl-L-fucosidase activity. They are exclusively bacterial in origin. The enzyme BT0984 from Bacteroides thetaiotaomicron is the only member of this family that has been characterized. This exo-acting enzyme targets the 2-O-methyl-L-fucose-α-1,2-D-Galp linkage in chain B of the complex pectin rhamnogalacturonan-II [1].
Kinetics and Mechanism
The stereochemistry of the reaction catalyzed by GH139 members has not yet been reported.
Catalytic Residues
Not known.
Three-dimensional structures
No three-dimensional structure has been solved for this family.
